The Relation between Self-Citation and Impact Factor in Medical Science Open Access Journals in ISI & DOAJ Databases

Citation is one of the important elements in scientific literature which has a significant role in information production and generation. Self-citation is a part of citation behavior. Relying on their articles, journals can change the number of citations and consequently the level of journal impact factor. This research aims at investigating the relation between self-citation and impact factor in the open access journals indexed in ISI and DOAJ in medical science in 2007-08. In this research, indexes such as the relation between self-citation of journal and impact factor and the effect of self-citation rate of the journal in open access performance are investigated. Research method is an analytical method conducted by using citation analysis technique. SPSS statistical software was used to examine and analyze the data and its inferential analysis methods such as Pierson Factor were used as well. Statistical society includes 168 journals. The results showed a self-citation rate of 28% for the journal. The findings indicate that there is a significant relation between self-citation and impact factor. After omitting self-citation, the level of self-citation in the performance of journals showed that 60% of the titles in the medical science experienced ranking increase, 27% experienced ranking decrease and 13% remained unchanged. Torabian R, Heidari A, Shahrifar M, Khodadi E, Esmaeile Vardanjani SA. The Relation between Self-Citation and Impact Factor in Medical Science Open Access Journals in ISI & DOAJ Databases. Life Sci J 2012;9(4):2206-2209] (ISSN: 1097-8135). http://www.lifesciencesite.com. 32

Autophagy in Hematological Malignancies: Molecular Aspects in Leukemia and Lymphoma

The organization of the hematopoietic system is dependent on hematopoietic stem cells (HSCs) that are capable of self-renewal and multilineage differentiation to produce different blood cell lines. Autophagy has a central role in energy production and metabolism of the cells during starvation, cellular stress adaption, and removing mechanisms for aged or damaged organelles. The role and importance of autophagy pathways are becoming increasingly recognized in the literature because these pathways can be useful in organizing intracellular circulation, molecular complexes, and organelles to meet the needs of various hematopoietic cells. There is supporting evidence in the literature that autophagy plays an emerging role in the regulation of normal cells and that it also has important features in malignant hematopoiesis. Understanding the molecular details of the autophagy pathway can provide novel methods for more effective treatment of patients with leukemia. Overall, our review will emphasize the role of autophagy and its different aspects in hematological malignant neoplasms. © American Society for Clinical Pathology 2020. All rights reserved. For permissions, please e-mail: [email protected]

The role of HDACs as leukemia therapy targets using HDI

Histone deacetylases (HDACs) are the enzymes causing deacetylation of histone and non-histone substrates. Histone deacetylase inhibitors (HDIs) are a family of drugs eliminating the effect of HDACs in malignant cells via inhibition of HDACs. Due to extensive effects upon gene expression through interference with fusion genes and transcription factors, HDACs cause proliferation and migration of malignant cells, inhibiting apoptosis in these cells via tumor suppressor genes. Over expression evaluation of HDACs in leukemias may be a new approach for diagnosis of leukemia, which can present new targets for leukemia therapy. HDIs inhibit HDACs, increase acetylation in histones, cause up- or down regulation in some genes and result in differentiation, cell cycle arrest and apoptosis induction in malignant cells via cytotoxic effects. Progress in identification of new HDIs capable of tracking several targets in the cell can result in novel achievements in treatment and increase survival in patients. In this review, we examine the role of HDACs as therapeutic targets in various types of leukemia as well as the role of HDIs in inhibition of HDACs for treatment of these malignancies

Mixed-phenotype acute leukemia characteristics: first report from Iran

Mixed-phenotype acute leukemia (MPAL) is the infrequent type of acute leukemia characterized by immunophenotypic and/or cytochemical features of both lineages, but the diagnosis of this disease still is a challenge. In this study, we analyzed immunophenotyping, cytochemistry and frequency of MPAL patients to better diagnosis of MPAL characteristics according to WHO 2016 criteria for the first time in Iran. In this retrospective study, 27 patients were diagnosed as MPAL based on WHO 2016 criteria during 2014�2017. Flow cytometric immunophenotyping was performed on PB and BM samples evaluation of different CD marker expressions in MPAL subsets. RT-PCR was performed for the analyses of BCR/ABL1 fusion in MPAL subsets. Among 27 cases, (70.4) 19 cases were B + My, (22.22) 6 cases were T + My, and 2 cases (7.40) were B + T + My. CD34, CD19, HLA-DR, TdT, CD22, iMPO were positive in majority of B + My cases. CD45, iMPO, iCD3, CD7, CD2 and CD5 were positive in majority of T + My cases. HLA-DR, TdT, CD10, CD22, iCD79a, iMPO, CD45, iCD3, CD7, CD3, CD2, CD5 were positive in majority of B + T + My cases. BCR/ABL1 fusion was positive for 3 cases (11.1) of p190 fusion and 2 cases (7.4) of p210 fusion in B + My cases. WHO 2016 criteria are the current standard for diagnosing MPAL. Also, evaluation of TdT, CD2, CD5, CD7 expressions by flow cytometry in EGIL criteria is useful for the better diagnosis of MPAL subsets. In addition, evaluation of BCR/ABL1 and MLL rearrangements in patients should be part of standard work-up in MPAL. © 2018 Springer Nature Switzerland A